june, 2019

05jun11:00 am12:00 pmEngineering Strategies for Improving Cancer Immunotherapy

Event Details

James Moon stands looking at the camera with an out of focus green background

James Moon, PhD,
John Gideon Searle Associate Professor, Pharmaceutical Sciences and Biomedical Engineering,
University of Michigan

Despite the clinical success of cancer immunotherapy, their dose-limiting toxicities and low patient response rates remain as the major challenges to address. Here, present new biomaterial-based strategies for amplifying anti-tumor immune responses and sensitizing tumors to immunotherapies in a safe and effective manner. Briefly, we show that lipid-based nanodiscs can efficiently co-deliver antigen and immunostimulatory molecules to draining lymph nodes and elicit potent CD8+ cytotoxic T lymphocyte responses, leading to substantially enhanced anti-tumor efficacy in multiple murine tumor models, including colon carcinoma, melanoma, and HPV-induced tumors. In a second research thrust, we have shown that this nano-platform can deliver chemotherapeutic agents in a synergistic manner with immune checkpoint blockers. Our nanotechnology offers a powerful and convenient platform for improving cancer immunotherapy.


(Wednesday) 11:00 am - 12:00 pm


IQ Atrium

775 Woodlot Dr

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