Current Opportunities

Research Associate (#508017) – Kanada Lab

The Institute for Quantitative Health Science and Engineering and the Department of Pharmacology & Toxicology at Michigan State University are seeking a Research Associate (postdoctoral fellow) in the Kanada Lab.

One Research Associate (postdoc) position is available in the laboratory of Dr. Masamitsu Kanada as a member of the Division of Synthetic Biology & Regenerative Medicine led by Dr. Assaf Gilad. The Institute for Quantitative Health Science and Engineering offers a unique environment for performing state-of-the-art multidisciplinary research with many of the top scientists in the field for understanding disease and developing early diagnostics and therapeutics.

The research project in the Kanada Lab includes:

(1) Understanding cell-to-cell communication via extracellular vesicles (EVs), specifically exosomes and microvesicles. Characterization of EV’s ability to send signals to tissue targets in the body for basic EV biology and clinical applications.

(2) Engineering EVs or generating biomimetic EVs to develop a novel gene delivery system for cancer therapy.

(3) Developing highly sensitive EV assays and high-throughput EV screens to identify druggable regulators of EV biogenesis.

To apply for this position, please visit the MSU Careers site.

Research Associate (#520181) – Gilad Lab

Two Research Associate (postdoctoral fellow) positions are available in the Gilad Lab in the Biomedical Engineering Department (BME) and the Institute for Quantitative Health Science and Engineering (IQ) at Michigan State University. The BME Department offers a unique environment for performing state of the art research with many of the top scientists in the field.

The research project focuses on:

-Constructing synthetic biology device in mammalian cells

-Imaging bioengineered cells in a rodent

-Developing innovative strategies for regenerative medicine

To apply for this position, please visit the MSU Careers site.

Research Associate (#523319) – Purcell Lab

The Department of Biomedical Engineering at Michigan State University is seeking a post-doctoral Research Associate in the Purcell Lab. The lab focuses on developing new approaches to investigate the biological mechanisms of suboptimal performance of electrode arrays implanted in the brain.

Specifically, the successful applicant will be expected to:
1- Substantially contribute to an ongoing project to assess the impacts of synaptic plasticity and neurotransmitter release on the performance of implanted electrode arrays in the brain. Experimental work will include rodent surgery, microscopy, immunohistochemistry, electrophysiology, and genetic engineering techniques.
2- Present findings at national conferences and publish work in peer-reviewed journals.
3- Support and advise graduate and undergraduate students assigned to the project.

To apply for this position, please visit the MSU Careers site.

Research Associate (#528563) – Smith Lab

A Research Associate (Postdoctoral Fellow) position is available in the Translational NanoImmunoEngineering (T-NIE) lab of Dr. Bryan Smith in the Biomedical Engineering Department (BME) and the Institute for Quantitative Health Science and Engineering (IQ). The BME department in IQ offers a unique environment for performing state-of-the-art research with many top scientists in the field, using advanced facilities. The Smith Laboratory is working at the interface of nanoengineering, imaging, and immunology to develop new strategies to therapeutically manipulate and visualize the immune system in living subjects. We develop novel nano-immunoimaging and nano-immunotherapy platforms employing a variety of experimental and computational approaches.

The projects relate primarily to pathological processes such as cancer and atherosclerosis and focus on:

1. Fabrication and characterization of novel nanoparticles

2. Immunological modulation

3. In vivo imaging, including but not limited to intravital microscopy and other optical and magnetic imaging technologies.

The successful candidate will also be expected to stay current on relevant literature related to the research projects, write manuscripts and funding applications such as fellowships, and mentor graduate and undergraduate students in the lab.

To apply for this position, please visit the MSU Careers site.

Research Associate (#565315)

The Institute for Quantitative Health Sciences and Engineering is called IQ for its dedication to the development of intelligent solutions to the most-pressing biomedical quandaries facing scientists and clinicians. To address these important problems, we have gathered some of the most creative minds from around the country to build integrative programs that bridge disciplines and integrate strategies for convergent tactical solutions.

Our research-oriented faculty bring to IQ a deep and wide set of multidisciplinary expertise bridging many areas of biomedical science. This expertise exists within a culture and architecture that fosters openness and collaboration and ensures convergence in science. This structure gives us the greatest chances of making discoveries and creating technologies that dramatically impact clinical care and fundamentally change our understanding of the basic biology of health and disease.

IQ is recruiting motivated research associates, postdoctoral researchers, to advance these fields and is inviting applications from outstanding candidates for up to 15 Postdoctoral positions in the several areas of biomedical research including; biomedical devices, biomedical imaging, chemical biology, developmental and stem cell biology, neuroengineering, structural biology, synthetic biology, systems biology, motion analytics and precision health.

To apply for this position, please visit the MSU Careers site.

Research Associate (#565878) – Aguirre Lab

The Institute for Quantitative Health Science & Engineering (IQ) invites applications from outstanding candidates for Research Associate, Postdoctoral, Positions (fixed-term research associate) in the field of Developmental and Stem Cell Biology.

The Aguirre Lab at Michigan State University focuses on investigating the pathways that control development, regeneration and cell fate, with an emphasis on the cardiovascular system. Our final goal is to understand and harness the regenerative power within our own cells and organs for therapy. The primary goal of the successful candidate will be to characterize the role of novel bioactive lipid signaling molecules and pathways in cardiovascular development, stem cell differentiation and regeneration. This will involve work with human iPSCs, transcriptomics, LC-MS-based mass spectrometry, cardiac organoids and animal models such as the mouse and zebrafish. The environment in the Aguirre Lab is highly multidisciplinary and collaborative. The successful candidate will also be expected to participate in related secondary projects and collaborations with other IQ labs. The Aguirre Lab is highly committed to the academic and professional development of our trainees.

The Aguirre lab is located in the brand-new Institute for Quantitative Health Science and Engineering (IQ) at MSU, and has a strong core of leading scientists working collaboratively across broad disciplines including: neuroengineering, motion analytics, developmental biology, stem cell biology, systems biology, synthetic biology, regenerative medicine, chemical biology and biomedical devices.

MSU provides competitive salary and excellent benefits for the position. This position will be funded for one year with renewal yearly, for up to three years, based upon funding and performance.

To apply for this position, please visit the MSU Careers site.

Research Associate (#582522) – Smith Lab

A Research Associate (Postdoctoral researcher) position is available in the Translational NanoImmunoEngineering (T-NIE) lab of Dr. Bryan Smith in the Biomedical Engineering Department (BME) and the Institute for Quantitative Health Science and Engineering (IQ). The BME department in IQ offers a unique environment for performing state-of-the-art research with many top scientists in the field, using advanced facilities. The Smith Laboratory is working at the interface of nanoengineering, imaging, and immunology to develop new strategies to therapeutically manipulate and visualize the immune system in living subjects. We develop novel nano-immunoimaging and nano-immunotherapy platforms employing a variety of experimental and computational approaches to treat and image cancer and atherosclerosis.

The projects relate primarily to pathological and inflammatory processes such as cancer and atherosclerosis. They focus on:

1. Immunological modulation, primarily of the innate immune system (in vitro and in vivo)

2. In vivo imaging, including but not limited to intravital microscopy and other optical and magnetic imaging technologies

3. Fabrication and characterization of novel nanoparticles

Job duties include but are not limited to:

· Performing laboratory work: culture, animal handling, biochemical assays, flow cytometry, immunological assays (e.g., cytokine, differentiation/activation, and T cell response assays), handling biological characterization of nanomaterials, and microscopy, including work with mouse modelscell

· Data acquisition, analysis, and interpretation.

· Operating and maintaining scientific instruments.

· Maintaining lab notebook and protocols.

The successful candidate will be expected to stay current on relevant literature related to the research projects, write manuscripts and funding applications such as fellowships, and mentor graduate and undergraduate students in the lab.

To apply for this position, please visit the MSU Careers site.

Research Associate (#618667) – Gilad Lab

A Research Associate (postdoctoral fellow) position is available in the Gilad Lab in the Department of Biomedical Engineering (BME) and the Institute for Quantitative Health Science and Engineering (IQ) at Michigan State University. The Department of BME offers a unique environment for performing state-of-the-art research with many of the top scientists in the field.

Research project focus:

· Developing novel algorithms for in silico protein and enzyme evolution

· De novo design of proteins and peptides based on desired function

· Validation in biological systems

The successful candidate will be expected to conduct experiments, collect and analyze data, give presentations about research, write papers and provide progress reports, and mentor undergraduate and graduate students in the lab.

To apply for this position, please visit the MSU Careers site.

Research Associate (#625364) – Pelled Lab

Two NIH funded research associate, postdoctoral, positions are available in Dr. Galit Pelled‘s Laboratory in the Department of Biomedical Engineering and the Institute for Quantitative Health Science and Engineering (IQ) at Michigan State University.

Research will focus on:

– Identifying fundamental sensorimotor circuits in octopus

– Developing innovative genetic and molecular-based neuromodulation technologies.

– Studying post-injury plasticity mechanisms in animal models of traumatic brain injury, peripheral nerve injury, spinal cord injury and epilepsy.

The successful candidate will be expected to conduct experiments, collect and analyze data, give research presentations, write scholarly papers, provide progress reports, and mentor graduate and undergraduate students in the lab.

To apply for this position, please visit the MSU Careers site.

Research Associate (#630006) – Bachmann Lab

The Institute for Quantitative Health Science and Engineering (IQ) and the Department of Microbiology and Molecular Genetics (MMG) at Michigan State University invite applications from outstanding candidates for the position of Research Associate (postdoctoral researcher) in the laboratory of Dr. Michael H. Bachmann.

The Bachmann Lab at IQ focuses on two biomedical issues of high public health significance: cancer immunology and antimicrobial resistance.  In the later project, the subject of this job announcement, we are investigating plant-derived compounds as alternative antibiotics.  According to the latest CDC report, ~35,000 Americans die from infections with antibiotic resistant bacteria.  We are therefore investigating complex plant compounds for their activity against gastrointestinal pathogens classified by the CDC as the biggest threats.  For in vitro screening and in vivo analysis, we are using bioluminescently labeled bacterial pathogens, such as E. coli, Salmonella, and Vibrio cholerae, and bioluminescence imaging to assess bacterial survival and thus antibacterial efficacy.  Our preliminary data show strong antibacterial activity of several plant compounds and extracts.

The primary goal of the successful candidate will be to further characterize these compounds, determine the signaling and metabolic pathways they affect through RNAseq and mutant analysis, assess cytotoxicity to mammalian cells, and test the compounds in mouse models of infection.  Job duties will also include, but are not limited to, mentoring undergraduate and graduate students in the lab; collaborate in related secondary projects and collaborations with other IQ and MMG labs; and write papers and give presentation about the research conducted.  The successful candidate will have knowledge of bacteriology, molecular biology and genetics, human and mouse cell culture assays, and experimental animal studies.  Knowledge of GC-MS-based mass spectrometry, transcriptomics, and large data analysis (R, Python, HPCC) will be given special consideration

To apply for this position, please visit the MSU careers site.

Research Associate (#637356) – Park Lab

The Institute for Quantitative Health Science and Engineering (IQ) at Michigan State University is seeking a post-doctoral Research Associate in the Park Lab.  The lab focuses on understanding fundamental principles that underlie tissue regeneration in a live animal by using in vivo imaging with multiphoton laser microscopy.

Regeneration is essential for multicellular life. It is a complex process that involves diverse cell types such as tissue-specific stem cells, their progeny and co-existing immune cells, but how these cell types interact to maintain homeostasis and to rebuild damaged tissue de novo has remained elusive. A major challenge to studying tissue regeneration has been the inability to visualize the cells in vivo over time. This limitation obscures insight into how individual and collective cellular behaviors, as well as interactions between distinct cell types, impact proper regeneration. To overcome this obstacle, we established a novel platform in live mammals which allows us to resolve individual epithelial cell behaviors that result in tissue-wide transformations during wound repair in the skin (Park et al. Nature Cell Biology 2017).

Our research overcomes major limitations in the field by combining novel imaging technology with genetic approaches, which allows us to capture dynamic behaviors in vivo during regeneration. Our long-term goal is to discover fundamental principles that underlie tissue regeneration in a live animal.

The Research Associate will have the opportunity to receive training on the use of cutting-edge in vivo imaging approach with transgenic mouse lines. The Research Associate will be fully engaged with the intellectual activities in the lab as well as in the institute.

The successful candidate will be an independent and highly motivated scientist, will be a collaborative member in a team environment, will have excellent experiment skills and publication record, and will have exceptional oral and written communication skills.

Application review will begin on March 2, 2020 and the position is open until filled.

To apply for this position, please visit the MSU careers site.