Current Opportunities

Research Associate (#528563) – Smith Lab

A Research Associate (Postdoctoral Fellow) position is available in the Translational NanoImmunoEngineering (T-NIE) lab of Dr. Bryan Smith in the Biomedical Engineering Department (BME) and the Institute for Quantitative Health Science and Engineering (IQ). The BME department in IQ offers a unique environment for performing state-of-the-art research with many top scientists in the field, using advanced facilities. The Smith Laboratory is working at the interface of nanoengineering, imaging, and immunology to develop new strategies to therapeutically manipulate and visualize the immune system in living subjects. We develop novel nano-immunoimaging and nano-immunotherapy platforms employing a variety of experimental and computational approaches.

The projects relate primarily to pathological processes such as cancer and atherosclerosis and focus on:

1. Fabrication and characterization of novel nanoparticles

2. Immunological modulation

3. In vivo imaging, including but not limited to intravital microscopy and other optical and magnetic imaging technologies.

The successful candidate will also be expected to stay current on relevant literature related to the research projects, write manuscripts and funding applications such as fellowships, and mentor graduate and undergraduate students in the lab.

To apply for this position, please visit the MSU Careers site.

Research Associate (#565315)

The Institute for Quantitative Health Sciences and Engineering is called IQ for its dedication to the development of intelligent solutions to the most-pressing biomedical quandaries facing scientists and clinicians. To address these important problems, we have gathered some of the most creative minds from around the country to build integrative programs that bridge disciplines and integrate strategies for convergent tactical solutions.

Our research-oriented faculty bring to IQ a deep and wide set of multidisciplinary expertise bridging many areas of biomedical science. This expertise exists within a culture and architecture that fosters openness and collaboration and ensures convergence in science. This structure gives us the greatest chances of making discoveries and creating technologies that dramatically impact clinical care and fundamentally change our understanding of the basic biology of health and disease.

IQ is recruiting motivated research associates, postdoctoral researchers, to advance these fields and is inviting applications from outstanding candidates for up to 15 Postdoctoral positions in the several areas of biomedical research including; biomedical devices, biomedical imaging, chemical biology, developmental and stem cell biology, neuroengineering, structural biology, synthetic biology, systems biology, motion analytics and precision health.

To apply for this position, please visit the MSU Careers site.

Research Associate (#582522) – Smith Lab

A Research Associate (Postdoctoral researcher) position is available in the Translational NanoImmunoEngineering (T-NIE) lab of Dr. Bryan Smith in the Biomedical Engineering Department (BME) and the Institute for Quantitative Health Science and Engineering (IQ). The BME department in IQ offers a unique environment for performing state-of-the-art research with many top scientists in the field, using advanced facilities. The Smith Laboratory is working at the interface of nanoengineering, imaging, and immunology to develop new strategies to therapeutically manipulate and visualize the immune system in living subjects. We develop novel nano-immunoimaging and nano-immunotherapy platforms employing a variety of experimental and computational approaches to treat and image cancer and atherosclerosis.

The projects relate primarily to pathological and inflammatory processes such as cancer and atherosclerosis. They focus on:

1. Immunological modulation, primarily of the innate immune system (in vitro and in vivo)

2. In vivo imaging, including but not limited to intravital microscopy and other optical and magnetic imaging technologies

3. Fabrication and characterization of novel nanoparticles

Job duties include but are not limited to:

· Performing laboratory work: culture, animal handling, biochemical assays, flow cytometry, immunological assays (e.g., cytokine, differentiation/activation, and T cell response assays), handling biological characterization of nanomaterials, and microscopy, including work with mouse modelscell

· Data acquisition, analysis, and interpretation.

· Operating and maintaining scientific instruments.

· Maintaining lab notebook and protocols.

The successful candidate will be expected to stay current on relevant literature related to the research projects, write manuscripts and funding applications such as fellowships, and mentor graduate and undergraduate students in the lab.

To apply for this position, please visit the MSU Careers site.

Research Associate (#630006) – Bachmann Lab

The Institute for Quantitative Health Science and Engineering (IQ) and the Department of Microbiology and Molecular Genetics (MMG) at Michigan State University invite applications from outstanding candidates for the position of Research Associate (postdoctoral researcher) in the laboratory of Dr. Michael H. Bachmann.

The Bachmann Lab at IQ focuses on two biomedical issues of high public health significance: cancer immunology and antimicrobial resistance.  In the later project, the subject of this job announcement, we are investigating plant-derived compounds as alternative antibiotics.  According to the latest CDC report, ~35,000 Americans die from infections with antibiotic resistant bacteria.  We are therefore investigating complex plant compounds for their activity against gastrointestinal pathogens classified by the CDC as the biggest threats.  For in vitro screening and in vivo analysis, we are using bioluminescently labeled bacterial pathogens, such as E. coli, Salmonella, and Vibrio cholerae, and bioluminescence imaging to assess bacterial survival and thus antibacterial efficacy.  Our preliminary data show strong antibacterial activity of several plant compounds and extracts.

The primary goal of the successful candidate will be to further characterize these compounds, determine the signaling and metabolic pathways they affect through RNAseq and mutant analysis, assess cytotoxicity to mammalian cells, and test the compounds in mouse models of infection.  Job duties will also include, but are not limited to, mentoring undergraduate and graduate students in the lab; collaborate in related secondary projects and collaborations with other IQ and MMG labs; and write papers and give presentation about the research conducted.  The successful candidate will have knowledge of bacteriology, molecular biology and genetics, human and mouse cell culture assays, and experimental animal studies.  Knowledge of GC-MS-based mass spectrometry, transcriptomics, and large data analysis (R, Python, HPCC) will be given special consideration

To apply for this position, please visit the MSU careers site.